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Anatabine and MS

Reprinted from PN/Paraplegia News April 2013

Drug found to reduce neurological disability and improve motor coordination in mice.

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Star Scientific, Inc., announced publication of the first peer-reviewed article examining the effects of anatabine in a mouse model of multiple sclerosis.

Researchers at the company’s research partner, The Roskamp Institute, found orally administered anatabine significantly reduced neurological disability and improved motor coordination of experimental autoimmune encephalomyelitis (EAE) mice.

In particular, paralysis of the hind limbs was markedly suppressed and neurological symptoms were delayed in the anatabine-treated group compared to the placebo group.

The investigators found that anatabine reduced the infiltration of inflammatory cells in the brain and significantly prevented demyelination of the spinal cord of EAE mice. In humans, demyelination in the spinal cord is associated with muscle weakness and paralysis in multiple sclerosis.

The study, “Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine,” is at http://dx.plos.org/10.1371/journal.pone.0055392.

It builds upon earlier research showing that the natural alkaloid anatabine displays anti-inflammatory properties and readily crosses the blood brain barrier, suggesting it could represent an important compound for mitigating many types of neuro-inflammatory conditions.

 

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Anatabine and MS

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